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AN EXPERIMENTAL STUDY ON THE BONE REGENERATION OF TIBIAL BONE DEFECT

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±è¼ö°ü/Su Gwan Kim ¿©È¯È£/±è¼ö¹Î/±è¼ö°ü/¿©È¯È£/±è¼ö¹Î/Hwan Ho Yeo/Soo Min Kim/Su Gwan Kim/Hwan Ho Yeo/Soo Min Kim

Abstract

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±¸°­¾Ç¾È¸éºÎÀ§ÀÇ °ñ°á¼ÕºÎ¸¦ Àç°ÇÇÒ °æ¿ì ÀÚ°¡°ñÀÌ ¿ì¼öÇϸç, ÀÛÀº °ñ°á¼ÕºÎ Àç°Ç¿¡ ÀÖ¾î
Àå°ñ(ilium)°ú ´Á°ñ(nb), µÎ°³°ñ(cranial bone)ÀÌ ¸¹ÀÌ »ç¿ëµÈ´Ù. ±×·¯³ª Àå°ñ¿¡¼­ äÃëÇÏ´Â
°æ¿ì¿¡´Â º¸ÇàÀå¾Ö, °¨¿°, ½Å°æÀÇ ¼Õ»ó°ú ´Á°ñ äÃëÇÏ´Â °æ¿ì´Â È丷ÀÇ ¿­Ã¢, Æó·Å, Ç÷Èä, ¹Ý
ÈçÇü¼º µî°ú °°Àº ÇÕº´ÁõÀÌ º¸°íµÇ°í ÀÖ´Ù. ±×·¡¼­ ÃÖ±Ù¿¡´Â ÀÌ·¯ÇÑ ÇÕº´ÁõÀ» ÇÇÇÏ°í ÀûÀý
ÇÑ ¾çÀÇ °ñ äÃë°¡ °¡´ÉÇÑ °ø¿©ºÎ·Î¼­ ÇÏÁöÀÇ °æ°ñ(tibia)¿¡¼­ ÀÚ°¡¸Á»ó°ñÀ» À̽ÄÇÏ´Â °æ¿ì
°¡ Áõ°¡ÇÏ°í ÀÖ´Ù. °ñ À̽Ľà ÇÇÁú°ñ°ú ¸Á»ó°ñÀº ¼­·Î ´Ù¸¥ Ä¡À¯¾ç»óÀ» º¸À̴µ¥, ÇÇÁú°ñ ÀÌ
½ÄÀº ¼ö¼ú Ãʱ⿡ ¿ì¼öÇÑ ±¸Á¶Àû ¾ÈÁ¤¼ºÀ» º¸ÀÌ°í, ¸Á»ó°ñ À̽ÄÀº Ãʱ⿡ ÀçÇ÷°üÈ­
(revascularization)°¡ ºü¸£°í ¿ÏÀüÇÑ °ñ ¼öº¹(bone repair)À» º¸ÀÌ¸ç °ñÇü¼ºÀÌ ¿Ï¼ºµÈ ÈÄ ¹°
¸®Àû °­µµ°¡ ¿ì¼öÇÏ¿© ÇÇÁú°ñº¸´Ù ´õ¿í À¯¿ëÇÑ ÀÌ½Ä ÇüÅ·Π¹Þ¾ÆÁö°í ÀÖ´Ù. ÀÌ¿Í°°ÀÌ ÀÚ°¡
¸Á»ó°ñÀÌ ¼öÇýºÎ¿¡ À̽ĵǾî Ä¡À¯µÇ´Â ¾ç»ó¿¡ ´ëÇÑ ¿¬±¸´Â È°¹ßÈ÷ ÀÌ·ç¾îÁ® ÀÖ´Â ¹Ý¸é °ø¿©
ºÎÀÇ °ñ°á¼ÕºÎ °ñÀÇ Àç»ý°úÁ¤¿¡ ´ëÇÑ ¿¬±¸´Â µå¹® ÇüÆíÀÌ´Ù. ±×·¡¼­ º» ¿¬±¸ÀÇ ¸ñÀûÀº ÃÖ±Ù
±¸°­¿Ü°ú¿¡¼­ ÀÚ°¡°ñ äÃëºÎÀ§·Î ¸¹ÀÌ ¾²´Â °æ°ñÀÇ °ñ°á¼ÕºÎ¿¡ ´ëÇÑ ½ÇÇèÀû ¿¬±¸·Î Àΰ£ÀÇ
Ä¡À¯°úÁ¤°ú ºñ½ÁÇÑ ¸ðµ¨·Î °³ÀÇ °æ°ñÀ» ¼±ÅÃÇÏ¿© ÀÚ°¡ ¸Á»ó°ñÀ» äÃëÇÑ ÈÄ¿¡ ¿ÜÃøÀÇ ÇÇÁú°ñ
À» Á¦°ÅÇÑ °æ¿ì¿Í ÇÇÁú°ñÀ» Á¦°ÅÇÏÁö ¾Ê°í ÀçÀ§Ä¡½ÃŲ °æ¿ì¿¡ ÀÖ¾î °¢°¢ ±× Ä¡À¯¸¦ ¾Ë¾Æº¸
°íÀÚ ÇÏ¿´´Ù.
#ÃÊ·Ï#
Recently, the clinical applications of the autogenous cancellous bone from the proximal
tibial metaphysis show satisfactory results in the repair of maxillofacial bony defect or
deformity. The proximal tibia has the potential to yield viable cancellous bone with a
minimum of morbidity.
The purpose of this study was to investigate the regeneration of a full thickness
proximal tibial bone defect with covering or uncovered of cortical bone. The follow-up
periods were 4, 8 weeks. Bone defect of right side was uncovered and left side was
covered with cortical bone.
In the experimental group(uncovered cortical bone) at 12 weeks, the inside of defect
was filled to normal marrow tissue. The cortical bone defect was united of inner, outer
callus at 4, 8 weeks in both study group. At 12 weeks, the cortical bone defect was
remodeled and invaded by osteoclast (giant cell) in experimental group. In the
experimental specimen at 12 weeks, the regenerating tissue of defect was not differ
from the control group.

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